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KMID : 0358420070500091205
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Korean Journal of Obstetrics and Gynecology
2007 Volume.50 No. 9 p.1205 ~ p.1215
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Expressions of cyclooxygenase-2 and P-glycoprotein in epithelial ovarian carcinomas
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Jung Soo-Kyoung
Kim In-Sun
Kang Jae-Seong
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Abstract
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Objectives: The purpose of this study was to evaluate expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in ovarian epithelial carcinomas, to find out the correlations between their expression and clinicopathological parameters, and to evaluate the response to treatment and clinical outcome according to their expression.
Methods: Immunohistochemical studies of COX-2 and P-gp were carried out in 64 cases that were treated with ovarian epithelial carcinomas at Department of Obstetrics and Gynecology, Korea University Hospital, Korea University from 1996 to 2005.
Results: COX-2 over-expression was detected in 20 (31.2%) cases and was significantly higher in non-responder than responder to chemotherapy (56.2% versus 22.9%, respectively; P=0.012). The patients of COX-2 overexpression showed shorter overall survival (P<0.001). Over-expression of P-gp was detected in 15 (23.4%) cases was significantly higher in non-responder than responder to chemotherapy (56.2% versus 12.5%, respectively; P<0.001). The patients of P-gp overexpression showed shorter overall survival (P= 0.042).
Conclusion: COX-2 and P-gp overexpression could provide additional information to identify ovarian carcinoma patients with poor chance of response to chemotherapy.
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KEYWORD
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COX-2, P-glycoprotein, Ovarian carcinoma, Chemotherpay, Prognosis
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